Although symptoms can appear as early as 7 days or as late as 1 year after infection, most people experience symptoms between 10 days to 4 weeks after infection. Typical symptoms resemble a flu-like illness, including fever, chills, headache and muscle aches, and tiredness. Nausea, vomiting, diarrhea, jaundice, and anemia can also occur. Malaria is also distinguishable for its "fever cycles" (a combination of chills, fever, and sweating), which can recur either every 48 or 72 hours depending on the species of Plasmodium. Severe malaria, however, can cause life-threatening organ failure, the manifestations of which can include kidney failure, seizures, bleeding, mental confusion, and coma.
Sometimes, the parasite can also remain dormant in the liver, and after hibernation (which can take as long as 4 years), can reenter the bloodstream and start infecting red blood cells, making a person sick.